The Red Devils boss told Inside United that he will happily give the Jamaican sprint legend his chance to take to the field in the club's annual charity clash against the Spanish giants next year.
And Fergie left open the tantalising possibility that if Bolt acquits himself well enough, there may be a chance for him to take his ambition of playing for the side further.
"Usain's a character and a big United fan," Ferguson said, "It's interesting he says he'd like to play in a charity game.
"It could be brilliant, and next year when we play Real Madrid's Legends again, there could be opportunities to bring him up and see how he does."
Bolt has always maintained that he would love to play football for United, and is certainly confident in his ability.
"I would not take up the challenge if I didn't think I was good enough," he said recently. "I am a very accomplished player and know I could make a difference.
"People think I am joking. But if Alex Ferguson called me up and said, ‘OK let's do this, come and have a trial', it would be impossible for me to say no."
Bolt recently spent the day as guest of honour at Old Trafford, being presented to fans on the pitch and meeting not just Ferguson, but also club legends Bobby Charlton, Ryan Giggs and Wayne Rooney.