The 24-year-old winger will serve a one-match ban after collecting his fifth booking of the season against Chesterfield.
His absence comes as a big blow to Adams having been ever-present so far this season, scoring seven goals.
Fellow midfielders Robert Taylor and Chris Shuker are expected to battle it out for a starting role.
Adams has no further injury or suspension worries ahead of the game as they look to return to winning ways.
Last weekend's defeat to in-form Chesterfield extended their losing streak to three matches in all competitions but Vale remain five points behind leaders Gillingham in second place.