The attacking duo both missed last weekend's victory over Dagenham, Constable with an ankle problem and Pittman with a hamstring injury sustained in the win over Wycombe, but look likely to come back into contention.
But captain Jake Wright looks set to miss out with a back injury which means Michael Duberry and Michael Raynes are likely to pair up in defence.
Oxford manager Chris Wilder will have to decide whether to stick with young goalkeeper Max Crocombe against Dale after his clean sheet in the 1-0 win over the Daggers last weekend.
The 19-year-old shotstopper, making just his second appearance, was a surprise inclusion and he will now be hoping to keep his place ahead of former Plymouth keeper Luke McCormick.
Left-back Tony Capaldi is fit again to join the squad, while youngsters Callum O'Dowda and Sam Long are both likely to continue on the bench.