Gareth Bale inspired under-par Spurs to a 2-1 victory against the French side on Thursday night, netting free-kicks in stoppage time of both halves.
The victory puts the north Londoners in the driving seat going into the return leg of their last-32 tie in France next week.
Villas-Boas believes an attacking mindset will give Tottenham the best chance of progressing as Samuel Umtiti's superb away goal leaves the tie delicately poised.
"It is difficult," the Portuguese said. "Their goal can obviously represent a lot for them.
"We are a team that normally scores away from home so we hope to cancel their away goal in some way.
"We are going to set out the same way - to try to attack and score.
"Even if they score before, we are going to attack to try to cancel out this goal. Obviously it gives them an initial advantage in the beginning."