The American, the lead figure in Fenway Sports Group who bought the Merseysiders in October 2010, has yet to attend a game this season, although business partner and Reds chairman Tom Werner has been present on occasions and will be again for the visit of Norwich on Saturday.
But Ayre insisted the lack of Henry's presence to see his second major sports investment - his other being the Boston Red Sox baseball team - does not mean anything. "I wouldn't read anything into John not being here," Ayre said.
"Two things: firstly he has had lot of work to do on the Boston Red Sox this year, they are approaching their pre-season now. Secondly, he also became a father again quite recently so he's likely been busy changing nappies!
"I speak to John very regularly and he's really pleased with the way things are going with the team. I know he keeps in contact with Brendan (Rodgers) regularly. I'm sure we will see him here soon.
"John's commitment to Liverpool isn't about him being at games. It's about him being involved and committed and being supportive. All that happens on a consistent basis. We get great support from both John and Tom.
"I was over in Boston recently and met with all the different investors in FSG and they are greatly supportive for what we're trying to achieve and are 100% behind us."
While results on the pitch have been mixed this season, Ayre believes progress is being made and Rodgers has always argued the addition of players in the next few transfer windows will help significantly.
Having bought Chelsea striker Daniel Sturridge for £12million, Liverpool's managing director said the investment in the squad would continue.
"There's still work to do but we're certainly pleased that we're progressing," he told the Liverpool Echo. "We will keep investing and adding to the group. Ultimately we will get to where we want to get to."