A run of one win in their last six games mean Fulham have fallen to 13th in the Barclays Premier League, just six points above the drop zone.
Although another defeat would dent morale even further, Jol knows the league is very much a priority for the London club and will therefore use the opportunity to rest Berbatov, who has played the last 16 games.
Jol also knows that even if Fulham overcome Blackpool, they are then likely to have to beat Manchester United to make it through to the fifth round, and will therefore rest a number of regulars in Lancashire even though it could mean his team are knocked out of the cup.
"I was really happy to get a draw against Blackpool (in the initial third round tie) and then I saw the draw," the Fulham manager said.
"I try to play the best team all the time and I feel we need to change the team for Blackpool to give players like Berbatov, who have played all the matches, a rest.
"But I have to make a decision on that because I still feel, under the circumstances, it is very important to stay in the FA Cup.
"It is always nice to have an extra opportunity to stay in this wonderful competition."