The French defender was suspended for Saturday's 1-1 draw with Accrington after he was dismissed for a second bookable offence against Exeter. Durrell Berry, who deputised in Blanchard's absence against Stanley, is expected to make way.
Fletcher is likely to stick with left-back Robbie Williams, who came through Saturday's game unscathed having been sidelined for over two months with a stomach muscle injury.
Bournemouth loanee Mark Molesley had his loan stay extended last week, meaning the 31-year-old is available for selection in this game, as well as the Pilgrims' clash with Wycombe on December 29.
Argyle, who sit 20th in npower League Two, go into the fixture looking to extend their unbeaten run to four league games.