Grant received his second red card of the season after scoring a fine equaliser during the 1-1 draw with Chesterfield earlier this month.
Peter Cavanagh, another ex-Stanley man, is a major doubt for boss Keith Hill having only returned to training on Monday from a troublesome calf complaint.
Dale midfielder Brian Barry-Murphy is relishing the prospect of a fiery derby atmosphere at Spotland.
"A lot of players say derby games are just another match but I always find they're quite a bit more exciting to play in and generally the atmosphere is better," he told his club's official website.
"There was a really good attendance at our last home game and everyone was delighted with that. I thought the atmosphere at the Torquay game was fantastic and hopefully that will be replicated on Tuesday night, and we can put on a performance to send them away happy again."