The Shrimpers will definitely be without long-term absentees Michael Timlin (broken leg) and Neil Harris (knee), while Brown will hand a late fitness test to Ben Reeves, who has been out with a calf injury.
Defender Luke Prosser is expected to keep his place in defence after returning from a back problem.
Goalkeeper Paul Smith could return to the starting XI having been sidelined by a virus. Daniel Bentley will continue in goal if Smith, who sat on the bench during Saturday's 2-1 defeat to York, is not ready to start.
Southend sit 11th in the league and are unable to qualify for the play-offs.