Bruno has been sidelined for the past five matches with an Achilles problem but is close to returning.
If manager Gus Poyet opts not to risk him, fellow Spaniard Inigo Calderon will continue at right-back.
Former Spain midfielder Vicente came through his first league start of the season in Tuesday's draw at Blackburn unscathed after recovering from a thigh injury and could keep his place.
Casper Ankergren may get another run-out in goal in place of Tomasz Kuszczak after playing in the third-round win over Newcastle.
Argentinian striker Leonardo Ulloa is still awaiting his debut following his recent switch from Spanish La Liga side Almeria.