Stuart McCall's side have scored 12 goals in three games against Caley Thistle this season but Butcher is looking forward to the opportunity to make amends against his former team.
"It's something we have to take on and I'm sure we will relish the opportunity. With our strongest team we have tried three times to match them and failed," he said.
"So there is no point looking back. All we can do is look forward to the match and apply ourselves even better than we have done before.
"We have had a great season and everything we have achieved has been through successful play - scoring goals, putting crosses into the box and taking the game to the opposition - and that's something we want to do this Saturday.
"It's not to be feared, it's to be eagerly anticipated. We have got to run our socks off, as simple as that.
"We have got to give maximum effort so we can come off the pitch and say 'I did my bit, I gave all I could', and hopefully that will get us three points."
Motherwell stretched their unbeaten run to eight games on Sunday with a 3-1 win over Celtic, their second victory over the Clydesdale Bank Premier League champions in two months.
The victory assured European football for Motherwell next season and they only need one more point to seal second place ahead of Caley Thistle.
Butcher's defence will be missing the suspended David Raven and the injured Gary Warren but he will focus on his side's positive approach as they look to join the Lanarkshire side in the Europa League. Butcher added: "We know what Motherwell can do. I saw the Motherwell-Celtic game and they were extremely impressive."