Caldwell, recently sidelined by a hamstring problem, was back in the squad for Saturday's 1-0 home defeat to Arsenal as an unused substitute and will be assessed by manager Roberto Martinez ahead of the short trip to Merseyside.
Fellow centre-back Ivan Ramis, who has also been nursing a hamstring complaint, has a chance of featuring as well, while midfielder James McCarthy (ankle) is a doubt.
Antolin Alcaraz (groin), Adrian Lopez (hamstring), Albert Crusat (knee), Ryo Miyaichi (ankle) and Ben Watson (broken leg) remain on the Latics' lengthy casualty list.
