The midfielder is sidelined for 10 weeks after rupturing ankle ligaments in the victory over Colchester. He was replaced by Harry Arter for the Boxing Day clash with Yeovil, who scored the second in a comfortable 3-0 victory.
The victory extended the Cherries' unbeaten run to 14 games but the previous 13 had all featured MacDonald in the midfield.
But Eddie Howe received a boost against Yeovil as Richard Hughes made his first appearance since October as a second half substitute. He will be pushing for further action against Crawley after recovering from his hamstring problem.
Long-term absentees Miles Addison, Darryl Flahavan, Stephen Purches and Charlie Sheringham remain sidelined.M