Clarke, whose side welcome Sunderland, concedes there could be up to six changes during the close season.
He recognises that the `not for sale' stance adopted by him during January will be harder to implement during the next transfer window.
Winger Jerome Thomas and striker Marc-Antoine Fortune are out of contract in June while frontman Roman Lukaku's season long loan will expire.
But in addition Albion could face further offers for the likes of striker Peter Odemwingie and defender Jonas Olsson after rejecting bids from QPR last month.
Clarke said: "The club always tend to have a number of players who are on short-term or loan contracts. At the end of the season there is a possibility there will be three, four, five or six changes.
"We've had a really good season and maybe some other, bigger clubs will show an interest in some of the players we've got.
"I would like to be able to take the same stance (not for sale) but the summer window is slightly different to the January window.
"It's a little bit longer, there's a little bit more time for us to have targets to go for and for other clubs to come in and try to take some of ours.
"Our job is to make sure that we have a number of targets ready to come in as and when we need to chase those targets."