Huddersfield, without a win in their last 12 league games, sacked manager Simon Grayson on Thursday after the club had slipped to within seven points of the relegation zone, while Clayton sustained a knee injury during last week's defeat at Watford.
Clayton was replaced at half-time by Keith Southern, who is expected to return to the starting line-up, although Oliver Norwood and Scott Arfield provide caretaker managers Mark Lillis and Steve Eyre with alternative options.
Danny Ward remains sidelined after breaking a bone in his foot. The unlucky winger missed five games with a knee problem and then suffered the latest injury in training last week when on the verge of a first-team comeback.
Defender Joel Lynch has missed the last three games with a hamstring injury and remains sidelined, but Town have no other new injury or suspension problems.
The Terriers, without a win in their last 12 league matches, won 1-0 at Charlton in the third round.
