The Republic of Ireland international limped off with a thigh problem during the second half of Everton's goalless draw with Southampton on Monday and has not recovered.
Boss David Moyes picked a strong side for the third-round win over Cheltenham and is likely to do so again, with fit-again winger Kevin Mirallas and defender Johnny Heitinga pushing for a start. Tony Hibbert (calf) and Darron Gibson (thigh) remain sidelined.
