Crainey has been virtually ever-present for the Seasiders this term but he picked up his fifth caution of the season in the 2-2 draw with Crystal Palace, meaning he will serve a one-game ban.
Blackpool boss Michael Appleton is likely to play Bob Harris, who spent time on loan with Rotherham earlier in the season, in his place.
Appleton has Chris Basham back for a one-game suspension and he will contend for a spot in midfield.
The Seasiders chief also revealed Gary Taylor-Fletcher will be included in the squad after returning to training following a hamstring problem.
Ian Evatt will not be included, although his knee injury is not thought to be as bad as first feared.
However, the defender picked up a bout of illness with Appleton hoping he will be well enough to return to training next week.
Forward Matt Phillips (toe) is a long-term injury absentee.