Arsenal may postpone their game against West Ham due the strike, which threatens travel chaos in the capital.
London Underground drivers are to stage three strikes, the first of which is scheduled for Boxing Day, in a row over Bank Holiday pay.
Members of Aslef will walk out for 24 hours on December 26, and again on January 18 and 25.
QPR and Fulham are also hosting Premier League games in the capital while in the Football League Charlton, Leyton Orient, AFC Wimbledon and the Daggers are at home, but all those matches are expected to go ahead.
The club told Press Association Sport: "At this moment in time there is no question of the game being called off. We are playing Southend and there is a mainline direct to Barking so they should not be disrupted."