Darikwa was substituted early in the second half for the second game running last weekend when he limped out of the 1-1 draw at Rochdale.
The winger has since seen a specialist and been told he requires a hernia operation that will keep him out for around a month.
Some good news for manager Paul Cook could see the return of Drew Talbot.
The versatile Talbot has been sidelined for a month because of a broken toe. Despite not kicking a ball since suffering the injury in the defeat at Wycombe on January 5, Cook has said Talbot will be recalled if he can prove his fitness.