A pre-selection of 25 players was named by coach Louis van Gaal for the matches against Hungary in Amsterdam on Oct. 11 and away in Istanbul four days later.
De Jong missed much of last season with an Achilles injury but has fought his way back to fitness at AC Milan while Van der Wiel has bedded down a regular place at Paris St Germain after a difficult initial season in Ligue 1.
It means there is again no place for 33-year-old Joris Mathijsen, who Van Gaal dropped for this month's qualifiers in Estonia and Andorra, where the Dutch picked up four points to ensure they became the first European country to qualify for the 2014 finals in Brazil.
Defenders: Daley Blind (Ajax), Jeffrey Bruma (PSV Eindhoven), Stefan de Vrij, Bruno Martins Indi, Daryl Janmaat (all Feyenoord), Gregory van der Wiel (Paris Saint Germain), Paul Verhaegh (FC Augsburg), Ron Vlaar (Aston Villa), Jetro Willems (PSV Eindhoven)
Midfielders: Jordy Clasie (Feyenoord), Jonathan de Guzman (Swansea City), Nigel de Jong (AC Milan), Stijn Schaars (PSV Eindhoven), Wesley Sneijder (Galatasaray), Kevin Strootman (Roma), Rafael van der Vaart (Hamburg SV)