The right-back was carried off on a stretcher towards the end of Leicester's 1-0 home defeat to Sheffield Wednesday on Saturday following a challenge from Owls midfielder Jeremy Helan.
His right leg was placed in a splint but scans after the game showed no break to any bones in his ankle or foot.
The fit-again Sean St Ledger and Zak Whitbread are ready to come into the team to replace De Laet.
Paul Konchesky missed out at the weekend with the hamstring injury that forced him off at half-time in the previous match against Leeds, so striker Jeff Schlupp again deputised as a makeshift left-back.
Konchesky may remain on the sidelines but the former England defender will be checked before manager Nigel Pearson finalises his plans.