Manchester United defender Patrice Evra claimed they now had the mental edge after Sunday's win at the Etihad Stadium, City's first home league defeat in almost two years.
Kompany brushed that off, however, and stressed the squad was focusing on this weekend's trip to Newcastle.
"I don't know anything about psychological blows," he said. "Losing on Sunday changes nothing. We lost and we move on to the next game.
"The beauty of football is that you are always challenged, whether you have lost or won, and the next game is always the most important.
"We all know the importance of the (Newcastle) game but I don't do very well in bad-scenario thinking.
"For me there are so many positives that can happen if we win that game - I can't think of the other side of that coin.
"We have done it many times before and we need to get back in that mindset. If we do that, good things will come for us.
"Newcastle away is just as difficult as the game we had on Sunday but nothing comes easy in the Premier League.
"It's a difficult game for us but it's also a tough one for Newcastle as well."