A shock 3-0 win at St James' Park, the Black Cats' first for 13 years, eased them three points clear of the drop zone - just two behind their hosts - with five games remaining, and handed the 44-year-old Italian his first success since replacing Martin O'Neill.
However, Di Canio knows they must put a glorious day on Tyneside to one side as they attempt to complete the job they started in such style.
Asked if the win at St James' Park was the best of his managerial career, he said: "Yes.
"I can't forget that I was manager at Swindon - it was my start and it was crucial. I won the league, I won many important games in the cup - when you are a League Two side and you beat Wigan, a Premier League side, it's an important moment for the club's history.
"But when you arrive at the top - because the Premier League is the top league in the world in my opinion, this is why I want to stay in England, because I love the people, I love the league, I love the atmosphere, the fans - and you win one of the hottest derbies in the world...
"It's difficult to find two cities very close, 15 miles [apart] that play at the top level, and they fight for the kingdom in this area.
"We won 3-0 away from home, three points, it's a fantastic moment.
"Now I have to tell you as a single game, it's the most important game for me - but it's nothing if we don't stay up."