The experienced centre-back has not played this campaign after suffering a serious neck injury at the end of last season, but has made good progress in recent weeks and is now back in full training.
U's boss Chris Wilder told the club's official website: "Michael has done very well and is in contention on Tuesday. Having someone of his strength and experience in and around the place is a big lift.
"He is a big character and a big player for us and it is excellent news to have him back."
Wilder will once again be without suspended midfielder Simon Heslop, who will serve the second game of a three-match ban.