Winger Holmes and striker Beavon appeared as second-half substitutes during North End's goalless draw at Portsmouth on Saturday having been restricted to the bench by illness but both players are now back to full fitness.
Chris Robertson will be missing from the Lilywhites' defence having picked up his fifth booking of the season and a one-match ban at Fratton Park.
Fellow defenders Keith Keane (knee) and Scott Laird (broken leg) are long-term absentees.
Preston's only win in their last six outings came in the first round of the FA Cup against Gillingham. They have overcome Carlisle and Morecambe in the Johnstone's Paint Trophy this term.