Leading scorer Adebayo Akinfenwa was rested against Aldershot on Saturday, withdrawn from the starting line-up due to a minor hip problem that has hampered him recently.
The 17-goal striker was on the bench for the 2-0 home win, coming on as a substitute midway through the second half.
Cobblers boss Aidy Boothroyd will decide on what the best course of action is regarding Akinfenwa for the game at the Globe Arena.
Chris Hackett is another important player who has been rested recently, but the midfielder marked his return to the starting XI with the opening goal against the Shots.
As well as Akinfenwa, Boothroyd has fellow forward Jake Robinson, midfielder Luke Guttridge and defenders John Johnson and Lee Collins available should he wish to make any changes to his team on Tuesday night.