The veteran centre-back will end his playing career later this month and turn his talents to television punditry.
Both he and Gerrard, Liverpool's Scouse heartbeat, have been involved in numerous games against their near-neighbours but this one will be particularly emotional.
Everton have not won at Anfield since 1999 and Gerrard does not want their rivals to end that streak in Carragher's last cross-city encounter.
"I think being a local lad we feel the passion in the city," said the England captain.
"Jamie will be playing at the weekend, he will be one of the first on the teamsheet and has been brilliant since he came back into the team.
"We're hoping to get a nice derby victory for Carra to remember because you will always remember your last derby."