Simonsen suffered a knee cartilage injury in Thursday night's 3-2 Johnstone's Paint Trophy defeat at Coventry and was hindered by the problem as the Sky Blues fired two goals in injury time to deny North End a place in the northern area final.
Thorsten Stuckmann is poised to deputise between the posts for the former Everton and Stoke man.
Defender Shane Cansdell-Sherriff is a major doubt having hobbled off to be replaced by Chris Robertson 18 minutes into the Ricoh Arena clash, although the nature of his problem is unknown.
Joe Garner is set to continue in attack alongside midweek goalscorer Stuart Beavon having made his North End debut.
Keith Keane (knee), fellow defender Scott Laird (broken leg) and forward Lee Trundle (hamstring) remain on the sidelines.