Hatem Ben Arfa's penalty and a Yoan Gouffran strike helped the Magpies come from behind to secure a victory that ensured another season in the top flight.
It had not always looked so plain sailing, though, with Loic Remy's early spot-kick putting Harry Redknapp's side ahead and ending a 376-minute wait for a goal.
Jose Bosingwa endured a forgettable afternoon. First Ben Arfa netted from the spot after being tugged back by the Portuguese, who then played a major part in the visitors' second. The right-back's weak back-pass was met by an equally poor attempt at a clearance by Robert Green, with Gouffran duly slotting home.
Bosingwa did not return for the second half and, despite goalkeeper Rob Elliott's late sending off, Newcastle held out.
QPR edged a poor opening that only came into life in the 11th minute when Mathieu Debuchy fouled Junior Hoilett and Remy slotted home the spot-kick.
Bosingwa then made a fantastic block to deny Cabaye, only to quickly become the villain once again. Ben Arfa burst into the box and the Portuguese undid his good work by foolishly tugging the Newcastle man's shirt and the France international stepped up to smash home.
Bosingwa's popularity then plummeted to a new low after sending a weak back-pass to Green who could only clear it as far as the unmarked Gouffran who made it 2-1.
Ben Arfa then drilled into the wall after Green picked up a back-pass from Armand Traore in the box. Gouffran shot wide soon after but Newcastle were living dangerously with a one-goal lead - something that looked even more tentative eight minutes from time when they were reduced to 10 men.
Newcastle goalkeeper Elliott handled the ball outside the box and was shown his second yellow of the afternoon, with Steve Harper replacing Ben Arfa for the closing stages.