The striker saw red just before half-time in Tuesday's goalless draw at Hartlepool following a challenge on defender Neil Austin.
U's manager Joe Dunne stressed post-match that he would be launching an immediate appeal against the harsh decision but, on further inspection of the rulebook this week, he has decided not to do so and Ibehre will now start a three-match suspension.
His unavailability comes as a blow at a time when Freddie Sears is again ruled out with the knee injury that forced him to miss the game at Victoria Park altogether, with Colchester now without their two leading goalscorers against the Alex.
But Dunne has moved to bolster his attacking options with the loan capture of Troy Hewitt from QPR until the end of the season and the striker is set to make his debut.
Captain Kem Izzet got another 90 minutes under his belt for the club's Under-21 side in midweek following his ankle injury and will hope to make the matchday 18.