Independiente and Quilmes are both in the Argentine first division's relegation standings, a separate table based on teams' average points over three seasons.
Independiente, record seven times South American champions, needed a good "Final" championship - the second of the season - if they are to avoid the drop in June but the Reds made a bad start last weekend.
They lost 3-1 at home to Newell's Old Boys after striker Ernesto Farias blasted a penalty over the bar with the score at 1-1 and their next match is away to champions Velez Sarsfield on Saturday.
"It happened at a key moment in the match. After the penalty the team dropped their heads," Farias said.
Quilmes may benefit from facing a weakened team if Tigre decide to field a majority of reserves to rest key players for Sunday's home clash with Boca Juniors and their Libertadores Cup Group 2 match against Paraguay's Libertad next week.
Tigre's December match was postponed because they were taking part in the final of the Copa Sudamericana, the region's equivalent of the Europa League.