The on-loan Newcastle midfielder sustained ankle damage when Alex went down 3-0 to Pompey's fellow strugglers Hartlepool in midweek.
The club's medical staff are hopeful the 21-year-old has only suffered heavy bruising as opposed to ligament damage but, either way, this weekend at Gresty Road probably comes too soon for him.
The Railwaymen's only other injury absentee is rookie defender Jon Guthrie, who is likely to be sidelined for a further two weeks with a groin problem.
Manager Steve Davis suggested he was ready to shuffle his pack in the wake of Tuesday's Victoria Park reverse.
Fit-again Matt Tootle and fellow defender Harry Davis could come in to add extra steel, while top scorer Mathias Pogba is hoping for an opportunity in attack.