The two npower Championship sides have a chance to make it to a Wembley semi-final, with the likes of Manchester United, Manchester City, Chelsea and Everton all potential opponents.
Jackett has seen his team lose four out of their last five home games, with only the 2-1 FA Cup success over Aston Villa giving the Lions supporters something to cheer about.
Despite their poor run Millwall go into the game as slight favourites and Jackett is hopeful that playing in front of their own fans can work as an advantage once again for his side.
"I just think it is a great opportunity, if you had a choice you would take a home game all day," he said.
"We are going to sell it out, pack the place, there will be a great atmosphere there and the crowd will be behind us and it is just a fantastic opportunity and if that makes us favourites we just have to look at the chance we have got.
"I think there is a big build-up to the game, you can see with the media attention which is great to see with the atmosphere generated in the build-up to the game.
"There is a different atmosphere and everyone is eager for the big game, which is live on television as well.
"It is a great prospect, it really is. It is something I haven't had as a manager and they have been good cup runs for both sides and I'm sure they feel the same.
"We have home advantage and we have to make that tell and we haven't done that of late - we need to use the crowd and feed off them."