James is nursing a knock following the 2-1 home defeat to Charlton on Tuesday night and the midfielder is rated doubtful.
His absence could pave the way for Andy King to return to the starting line-up.
With striker Chris Wood making a goalscoring return from a knee injury against Charlton, winger Ben Marshall also back in the side for the Addicks' visit after an ankle problem and defender Sean St. Ledger on the bench after a lengthy absence with a hamstring injury, Foxes boss Nigel Pearson has an otherwise full strength squad at his disposal as he looks to get Leicester's promotion challenge back on track.
He has also signed Harry Kane ahead of the trip and the Tottenham striker, who will remain with Leicester for the remainder of the season, will go straight into the squad at Bloomfield Road.