The former Everton and Arsenal striker joined Stanley until the end of the season last week and appeared as a second-half substitute during Saturday's 2-0 defeat at Northampton.
Jeffers replaced Craig Lindfield, who made a surprise return from an ankle injury and is set to be involved once more.
Accrington's other ex-England international forward, James Beattie, was rested at the weekend and is expected to return against the Cod Army.
Amine Linganzi was handed a maiden Reds start in midfield at Sixfields and will hope to win favour with Richardson once more, while defender Michael Liddle should be available once more following a bout of illness.
