The Frenchman starts a three-match ban after he was sent off for kicking out at Nottingham Forest's Greg Halford during the Addicks' 2-0 defeat last weekend.
His absence could pave the way for a full debut for on-loan Tottenham frontman Jon Obika, who came on as a late sub against Forest.
Ricardo Fuller and Danny Haynes are also in contention for places in attack.
Midfielder Danny Hollands is still missing with a foot injury but Powell has an otherwise fully-fit squad to choose from.
Lawrie Wilson could return after dropping to the bench against Forest, while Salim Kerkar may be added to the squad having missed out at the weekend.