Leitch-Smith has been sidelined by an ankle problem since the Railwaymen's 2-0 defeat at Portsmouth in November, but has returned to full training and boss Steve Davis will assess his match fitness.
Abdul Osman is available once more in midfield following a minor knee injury, however Ollie Turton (thigh) and goalkeeper Steve Phillips (ankle/shin) miss out.
Alex are chasing a third consecutive league win for the first time this season after back-to-back triumphs over Preston and Bury.
They were denied the opportunity to make it three in a row on Saturday when the home clash with in-form Bournemouth was postponed after a torrential downpour left the Gresty Road playing surface waterlogged.
