The on-loan pair were ineligible for last weekend's FA Cup victory over Fleetwood but make their comebacks at the Kassam Stadium to boost manager Dean Holdsworth's options.
Both players are welcome additions to Holdsworth's squad, with Stevenage striker Lopez having bagged three goals in three games prior to his omission against The Cod Army.
He is likely to partner Danny Hylton in attack after his brace helped see off Fleetwood 3-2.
Fit-again Craig Reid returned from a knee injury to start the FA Cup tie but he is likely to drop to the bench.
Goalkeeper Ross Worner made his first appearance since February in a midweek Hampshire Senior Cup tie having overcome a serious back injury, although it remains to be seen whether he will make the matchday 18 so soon.