The three Clydesdale Bank Premier League games between the clubs this season have ended in draws as both sides ended up in the bottom six.
However, Hibs knocked the Jambos out of the William Hill Scottish Cup on their way to the final against Celtic, which is to be played later this month
Asked what a win in the final derby of the campaign would mean to Hearts, MacDonald, 27, said: "I suppose bragging rights over your city rivals.
"It is the last game to get a win over them, we have not beaten them this season.
"We have had three draws and they have put us out the cup.
"So it is a chance to get a win and also we would be in pole position to finish above them in the league which I think after the season we have had it would make the season slightly bearable.
"We have won three out of our last four games and even the game we lost against Dundee, the red card for Webby (Andy Webster) changed the game and it was a deflected goal as well.
"So we have been on a decent run of form and have got a bit of momentum.
"If we can win the last two games of the season it would be a good end to the season and gives everyone a lot of confidence going into next season."