Interim manager Alan Knill was without his ill skipper as they lost at home to Wycombe in midweek and the former Bury boss admitted Mansell was a big loss against the Chairboys.
But the long-serving midfielder should return at The Crown Ground, a venue that has seen just one Gulls victory, back in 1930.
Knill hopes to have at least one new face on board before the trip especially in the absence of centre back Aaron Downes with a hamstring injury.
Craig Easton had to be taken off in midweek with a niggling calf injury and he will be assessed.
If the Gulls are beaten by Accrington it be their eighth successive league loss, their worst run of form since the autumn of 1995.