The 21-year-old striker returned to full training on Thursday having recovered from a toe injury.
That problem forced the nine-goal forward to come off in the defeat to Bristol Rovers on Saturday but he is set to be available to face Paul Sturrock's men.
QPR loanee Bruno Andrade will again be assessed ahead of kick-off to determine whether he can rejoin the squad having sat out their last match with an ankle knock picked up against Bradford.
Wycombe go into this match in 14th position in npower League Two, 10 points below the play-off places and 10 clear of the relegation zone.
Southend ran out 1-0 winners when the teams met at Roots Hall back in September.