The Royals remain bottom of the Barclays Premier League table following Tuesday night's 5-2 hammering at home by Arsenal. The Berkshire's Russian owner Anton Zingarevich maintains funds will be available to bring in fresh faces in the new year.
McDermott reckons players with top-flight experience could prove pivotal in the club's relegation fight, and revealed he has spoken to Zingarevich about potential targets.
"It would be good to see if we could get two or three players who have played at the top level," he said. "They need to know the level and have played there and been there, seen it and done it, whether we can do that or not time will tell and we will see.
"I had a discussion (with Zingarevich), we had a four hour meeting the other day and talked about players coming through the door."
The Royals brought in eight new signings after winning the npower Championship last season, but McDermott's squad is still short on Premier League experience.
The 51-year-old admits the club will never be able to compete with the spending power of some teams in the league and that Reading's current standing in the table could also act as a deterrent to any potential new signings.
"January is a very difficult window, especially if you are struggling and are where we are in the league," he said.
"I can't see this club ever spending a fortune in January, I just don't think it is going to happen. Having said that we have to try and find some experience to come through the door for us.
"I think that if we can, they are the kind of players we should be going for."