Mee received his marching orders for two yellow cards in quick succession before the Clarets failed to hold out for an historic east Lancashire derby triumph over Blackburn last time out.
Danny Lafferty is expected to step in at left-back, having deputised for Mee during much of 2013 after his team-mate suffered medial knee ligament damage.
Boss Sean Dyche must once again do without Dean Marney (calf) in midfield as he searches for a second win in 11 outings on his first return since being dismissed at Vicarage Road last summer.
"I've made it clear many times, I don't really do old club scenarios," he told Burnley's official website. "I didn't do it at Millwall and I won't do it at Watford.
"I respect them, I enjoyed my time there and I learnt a lot from it but (Friday) is just about winning.
"It is about getting ourselves right to win a football match and going to deliver a performance to win a football match. It just so happens that it is at Watford."