Moore's men ground out the victory over struggling Scunthorpe, courtesy of Cole Stockton's second half goal, to regain top spot in League One as Sheffield United crashed to a shock home defeat against bottom club Hartlepool.
"You have to grind games out at this time of the seasons and there are one or two tired legs out there, but a pat on the back, they kept going," said Moore.
"We've got to win our home games and grind it out. That's what happens when you've got four players missing, and if you put them back in the team, who knows what will happen.
"All we've got to do is our job, and you never know where's it's going to finish. Who'd have thought Hartlepool would go and win at Sheffield United? There are plenty of twists and turns to come.
"We changed it around at half-time - the way we played - and went 4-3-3, put Adam McGurk in behind the strikers, and it worked to be fair.
"Cole changed our style, but they've got two big monster centre backs, and don't want pace, which is why you're a bit reluctant to have young Cole in there. He's done what all good strikers do, he's sniffed out the goal and it was nice when it went in, because it looked like it was never going to happen."
Scunthorpe manager Brian Laws cut a frustrated figure at full time, but took heart from the way his side competed with their high-flying hosts.
"We're disappointed because I thought we bossed the first half," he said. "It was nip and tuck in the second half, but that just shows that Tranmere had to change their style and formation to adapt."
"They couldn't penetrate through us - I thought we were very resilient. We passed well when we could, but there was nothing between the sides, which shows how open this league is."