Mourinho puts his unbeaten run of 62 Premier League matches at Stamford Bridge on the line against west London neighbours Fulham in the week the Blues lost a home Champions League group game for the first time in nearly 10 years.
Chelsea have also made their worst start to a Premier League season in a decade - winning only against Hull and Aston Villa, while drawing at Manchester United and losing at Everton - in an inauspicious opening to Mourinho's second spell as boss.
The solution for Mourinho is simple.
"We need to score goals," Mourinho told Chelsea TV following the Basle defeat, Chelsea's first in 29 group-stage matches at home.
"When you don't score goals you are in trouble."
Following the Basle blow the self-proclaimed Special One insisted he was happy with his strike options - Samuel Eto'o, Fernando Torres and Demba Ba - despite lamenting the failure to find the net.
The more worrying thing for the Portuguese may be that his side, unusually for a team under his stewardship, were porous at the back.
Branislav Ivanovic is confident Chelsea can make amends in the Champions League.
"It's a bad start in the Champions League but it's just the first game," the Serbia defender said.