United will attempt to put their troubled Premier League form behind them when they take on Shakhtar Donetsk in the Donbass Arena.
Victory would allow them to take a firm grip on their Champions League group, which in turn might make it easier for Moyes to rotate his squad with greater effectiveness.
For, after successive league defeats to Manchester City and West Brom, Moyes acknowledges he still needs to get the balance right.
"We will be looking for a balance of experience and youth," he said.
"We will be trying to introduce new young players at the right times but also rely a lot on the great experience many of the players have at Manchester United."
Two players at either end of the spectrum, Rio Ferdinand and Wilfried Zaha, have been omitted from the United travelling party altogether.
Anderson's absence means there must be at least two changes from the team beaten by West Brom.
Yet Moyes is not worried by the claims of Shakhtar's veteran coach Mircea Lucescu that too much rotation is one of the major reasons for United's inconsistent form.
"It never caused Sir Alex Ferguson any problem when he did it," he said.
This scrutiny is what Moyes opened himself up to when he accepted the challenge of succeeding Sir Alex Ferguson last spring.
"It is always the thing at Manchester United," said Moyes.
"Everyone is interested in them. It is a talking point for everybody throughout the world. That is why it is, for me, the greatest club.
"It is a great honour to be the manager. Even our arrival here in Donetsk has been greeted with a lot of supporters at the airport."
And, in the knowledge senior figures within the Red Devils camp, not least Sir Bobby Charlton and Sir Alex Ferguson, will ensure he gets the time needed to implement his plans, Moyes spoke with an air of certainty.
"I have been in situations very similar to this at my old clubs Everton and also at Preston," he said.
"You get on and you do the right things. I haven't changed what I have done. I will continue to do that. The results will come. I have no doubt about that."