Murphy has missed the last three games with a groin problem and now faces a race against time to prove his fitness before the end of the campaign.
Goalkeeper Steve Phillips reclaimed his starting place for the 1-0 defeat at Yeovil on Saturday and is set to continue at the expense of Alan Martin.
Manager Steve Davis made three further changes for the Glovers clash with Abdul Osman making an immediate return to the first XI following a two-match ban and Bradden Inman and Ajay Leitch-Smith recalled.
Oliver Turton, Michael West and Kevin Stewart were the men to make way while Mark Ellis recovered from his ankle problem to retain his starting spot.
Adam Dugdale has returned to training following compassionate leave but will not feature while Mathias Pogba (thigh) and defender Gregor Robertson (Achilles) are ruled out for the season.