The Seasiders are in talks with Dundee United boss Peter Houston over replacing Michael Appleton, who left to take charge at Blackburn after just 66 days at Bloomfield Road.
Defender Ian Evatt remains sidelined with a bruised knee, while winger Matt Phillips continues his recovery from a toe injury.
The 21-year-old Scotland international last featured during November's 2-2 draw with Bolton - the first game of Appleton's brief tenure.
Stephen Crainey returned at left-back for Saturday's 2-1 defeat to Charlton, but Bob Harris could feature again with Thompson likely to shuffle his pack.
Gary Taylor-Fletcher overcame a back injury to take up a place on the bench at The Valley and is set to be included once more as Pool chase a fourth-round trip to Manchester United.