The Chairboys recorded impressive wins over Torquay and Fleetwood before the disappointing defeat at Spotland which left them 11 points clear of the relegation zone ahead of the clash with the Millers.
"We're still 14th and there's still a lot of teams beneath us," player-manager Gareth Ainsworth told the club's official website.
"I still want another win to make sure. There are things to work on and I'll be a busy man in the lead up to the Rotherham game."
Should Ainsworth decide to ring the changes the likes of Jo Kuffour, Bruno Andrade and Leon Johnson could be given the nod against an in-form Rotherham side just two points off the automatic promotion places.