The Cherries boss, who saw his side make it three wins on the bounce against Bury last weekend, has the option of recalling captain Tommy Elphick to the starting line-up as the defender continues his recovery back to full fitness.
Howe admits he will have to look at rotating his squad for the home game with Scunthorpe on Monday but says he will play his best possible team against the struggling U's.
Brett Pitman is set to get the nod up front again having scored four in his last five appearances for a Bournemouth side who are only outside the automatic promotion places on goal difference.
The forward has been in excellent form since winning his place back in the side, scoring four in his last five appearances.
Long-term absentees Miles Addison, Stephen Purches and Stephane Zubar remain sidelined.